A genome-wide screen indicates correlation between differentiation and expression of metabolism related genes.

ABSTRACT: Differentiated tissues may be considered as materials with distinct properties. The differentiation program of a given tissue ensures that it acquires material properties commensurate with its function. It may be hypothesized that some of these properties are acquired through production of tissue-specific metabolites synthesized by metabolic enzymes. To establish correlation between metabolism and organogenesis we have carried out a genome-wide expression study of metabolism related genes by RNA in-situ hybridization. 23% of the metabolism related genes studied are expressed in a tissue-restricted but not tissue-exclusive manner. We have conducted the screen on whole mount chicken (Gallus gallus) embryos from four distinct developmental stages to correlate dynamic changes in expression pat

SUBMITTER: Roy P 

PROVIDER: S-EPMC3661535 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature