Ontology highlight
ABSTRACT:
SUBMITTER: Malinouski M
PROVIDER: S-EPMC5578452 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Nature communications 20140101
Trace elements are essential for human metabolism and dysregulation of their homoeostasis is associated with numerous disorders. Here we characterize mechanisms that regulate trace elements in human cells by designing and performing a genome-wide high-throughput siRNA/ionomics screen, and examining top hits in cellular and biochemical assays. The screen reveals high stability of the ionomes, especially the zinc ionome, and yields known regulators and novel candidates. We further uncover fundamen ...[more]