Ontology highlight
ABSTRACT:
SUBMITTER: Lee EJ
PROVIDER: S-EPMC3661549 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Lee Eun Ju EJ Bhat Abdul R AR Kamli Majid Rasool MR Pokharel Smritee S Chun Tahoon T Lee Yong-Ho YH Nahm Sang-Seop SS Nam Joo Hyun JH Hong Seong Koo SK Yang Bohsuk B Chung Ki Young KY Kim Sang Hoon SH Choi Inho I
PloS one 20130522 5
Transthyretin (TTR) is a known carrier protein for thyroxine (T4) and retinol-binding protein in the blood that is primarily synthesized in the liver and choroid plexus of the brain. Herein, we report that the TTR gene is expressed in skeletal muscle tissue and up-regulated during myotube formation in C2C12 cells. TTR silencing (TTRkd) significantly reduced myogenin expression and myotube formation, whereas myogenin silencing (MYOGkd) did not have any effect on TTR gene expression. Both TTRkd an ...[more]