Ontology highlight
ABSTRACT:
SUBMITTER: Moon YA
PROVIDER: S-EPMC3662050 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Moon Young-Ah YA Liang Guosheng G Xie Xuefen X Frank-Kamenetsky Maria M Fitzgerald Kevin K Koteliansky Victor V Brown Michael S MS Goldstein Joseph L JL Horton Jay D JD
Cell metabolism 20120201 2
Insulin resistance leads to hypertriglyceridemia and hepatic steatosis and is associated with increased SREBP-1c, a transcription factor that activates fatty acid synthesis. Here, we show that steatosis in insulin-resistant ob/ob mice was abolished by deletion of Scap, an escort protein necessary for generating nuclear isoforms of all three SREBPs. Scap deletion reduced lipid synthesis and prevented fatty livers despite persistent obesity, hyperinsulinemia, and hyperglycemia. Scap deficiency als ...[more]