Ontology highlight
ABSTRACT:
SUBMITTER: Cheng C
PROVIDER: S-EPMC4643405 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Cheng Chunming C Ru Peng P Geng Feng F Liu Junfeng J Yoo Ji Young JY Wu Xiaoning X Cheng Xiang X Euthine Vanessa V Hu Peng P Guo Jeffrey Yunhua JY Lefai Etienne E Kaur Balveen B Nohturfft Axel A Ma Jianjie J Chakravarti Arnab A Guo Deliang D
Cancer cell 20151101 5
Tumorigenesis is associated with increased glucose consumption and lipogenesis, but how these pathways are interlinked is unclear. Here, we delineate a pathway in which EGFR signaling, by increasing glucose uptake, promotes N-glycosylation of sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP) and consequent activation of SREBP-1, an ER-bound transcription factor with central roles in lipid metabolism. Glycosylation stabilizes SCAP and reduces its association wit ...[more]