Ontology highlight
ABSTRACT:
SUBMITTER: Gamazon ER
PROVIDER: S-EPMC3663430 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Gamazon Eric R ER Lamba Jatinder K JK Pounds Stanley S Stark Amy L AL Wheeler Heather E HE Cao Xueyuan X Im Hae K HK Mitra Amit K AK Rubnitz Jeffrey E JE Ribeiro Raul C RC Raimondi Susana S Campana Dario D Crews Kristine R KR Wong Shan S SS Welsh Marleen M Hulur Imge I Gorsic Lidija L Hartford Christine M CM Zhang Wei W Cox Nancy J NJ Dolan M Eileen ME
Blood 20130328 21
A whole-genome approach was used to investigate the genetic determinants of cytarabine-induced cytotoxicity. We performed a meta-analysis of genome-wide association studies involving 523 lymphoblastoid cell lines (LCLs) from individuals of European, African, Asian, and African American ancestry. Several of the highest-ranked single-nucleotide polymorphisms (SNPs) were within the mutated in colorectal cancers (MCC) gene. MCC expression was induced by cytarabine treatment from 1.7- to 26.6-fold in ...[more]