Ontology highlight
ABSTRACT:
SUBMITTER: Przybyla LM
PROVIDER: S-EPMC3664106 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Przybyla Laralynne M LM Theunissen Thorold W TW Jaenisch Rudolf R Voldman Joel J
Stem cells (Dayton, Ohio) 20130601 6
While a variety of natural and synthetic matrices have been used to influence embryonic stem cell (ESC) self-renewal or differentiation, and ESCs also deposit a rich matrix of their own, the mechanisms behind how extracellular matrix affects cell fate are largely unexplored. The ESC matrix is continuously remodeled by matrix metalloproteinases (MMPs), a process that we find is enhanced by the presence of mouse embryonic fibroblast feeders in a paracrine manner. Matrix remodeling by MMPs aids in ...[more]