Tumor-targeting multifunctional micelles for imaging and chemotherapy of advanced bladder cancer.

ABSTRACT: This work aimed to determine if the treatment outcomes of bladder cancer could be improved by targeting micelles that are decorated with bladder cancer-specific ligands on the surface and loaded with the chemotherapeutic drug paclitaxel.Targeting efficacy and specificity was determined with cell lines. An in vivo targeting and anti-tumor efficacy study was conducted in mice carrying patient-derived xenografts.Targeting micelles were more efficient than nontargeting micelles in delivering the drug load into bladder cancer cells both in vitro and in vivo (p < 0.05). The micelle formulation of paclitaxel was less toxic than free paclitaxel in Cremophor(®) (Sigma, MO, USA) and allowed administration of three-times the maximum tolerated dose without increasing the toxicity. Targeting micelles were more effective than the nontargeting micelles in controlling cancer growth (p = 0.0002) and prolonging overall survival (p = 0.002).Targeting micelles loaded with paclitaxel offer strong potential for clinical applications in treating bladder cancer.

SUBMITTER: Lin TY 

PROVIDER: S-EPMC3664656 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature