Ontology highlight
ABSTRACT:
SUBMITTER: Barriga EH
PROVIDER: S-EPMC3664719 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
The Journal of cell biology 20130501 5
One of the most important mechanisms that promotes metastasis is the stabilization of Hif-1 (hypoxia-inducible transcription factor 1). We decided to test whether Hif-1α also was required for early embryonic development. We focused our attention on the development of the neural crest, a highly migratory embryonic cell population whose behavior has been likened to cancer metastasis. Inhibition of Hif-1α by antisense morpholinos in Xenopus laevis or zebrafish embryos led to complete inhibition of ...[more]