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New views on the neural crest epithelial-mesenchymal transition and neuroepithelial interkinetic nuclear migration.

ABSTRACT: By developing a technique for imaging the avian neural crest epithelial-mesenchymal transition (EMT), we have discovered cellular behaviors that challenge current thinking on this important developmental event, including the probability that complete disassembly of the adherens junctions may not control whether or not a neural epithelial cell undergoes an EMT. Further, neural crest cells can adopt multiple modes of cell motility in order to emigrate from the neuroepithelium. We also gained insights into interkinetic nuclear migration (INM). For example, the movement of the nucleus from the basal to apical domain may not require microtubule motors nor an intact nuclear envelope, and the nucleus does not always need to reach the apical surface in order for cytokinesis to occur. These studies illustrate the value of live-cell imaging to elucidate cellular processes.

SUBMITTER: Ahlstrom JD

PROVIDER: S-EPMC2829823 | biostudies-other | 2009 Nov

REPOSITORIES: biostudies-other

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New views on the neural crest epithelial-mesenchymal transition and neuroepithelial interkinetic nuclear migration.

Ahlstrom Jon D JD Erickson Carol A CA

Communicative & integrative biology 20091101 6

By developing a technique for imaging the avian neural crest epithelial-mesenchymal transition (EMT), we have discovered cellular behaviors that challenge current thinking on this important developmental event, including the probability that complete disassembly of the adherens junctions may not control whether or not a neural epithelial cell undergoes an EMT. Further, neural crest cells can adopt multiple modes of cell motility in order to emigrate from the neuroepithelium. We also gained insig ...[more]

PMID: 20195454

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