Ontology highlight
ABSTRACT:
SUBMITTER: Malcolmson SJ
PROVIDER: S-EPMC3666682 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Malcolmson Steven J SJ Young Travis S TS Ruby J Graham JG Skewes-Cox Peter P Walsh Christopher T CT
Proceedings of the National Academy of Sciences of the United States of America 20130506 21
Berninamycin is a member of the pyridine-containing thiopeptide class of antibiotics that undergoes massive posttranslational modifications from ribosomally generated preproteins. Berninamycin has a 2-oxazolyl-3-thiazolyl-pyridine core embedded in a 35-atom macrocycle rather than typical trithiazolylpyridine cores embedded in 26-atom and 29-atom peptide macrocycles. We describe the cloning of an 11-gene berninamycin cluster from Streptomyces bernensis UC 5144, its heterologous expression in Stre ...[more]