Ontology highlight
ABSTRACT:
SUBMITTER: Christen B
PROVIDER: S-EPMC3666714 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Christen Barbara B Damberger Fred F FF Pérez Daniel R DR Hornemann Simone S Wüthrich Kurt K
Proceedings of the National Academy of Sciences of the United States of America 20130506 21
Two lines of transgenic mice expressing mouse/elk and mouse/horse prion protein (PrP) hybrids, which both form a well-structured β2-α2 loop in the NMR structures at 20 °C termed rigid-loop cellular prion proteins (RL-PrP(C)), presented with accumulation of the aggregated scrapie form of PrP in brain tissue, and the mouse/elk hybrid has also been shown to develop a spontaneous transmissible spongiform encephalopathy. Independently, there is in vitro evidence for correlations between the amino aci ...[more]