Ontology highlight
ABSTRACT:
SUBMITTER: Brueseke TJ
PROVIDER: S-EPMC3666910 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Brueseke Taylor J TJ Tewari Krishnansu S KS
Clinical pharmacology : advances and applications 20130523
Ovarian cancer is the most deadly gynecologic cancer, with 15,000 anticipated deaths within the United States alone in 2012, and new treatment strategies are needed. Ovarian cancer tumors are known to host an immunosuppressive microenvironment. This suppression may be reversible via activation of the innate immune response. Toll-like receptor 8 activates innate immunity while simultaneously inhibiting the effects of regulatory T cells within the ovarian cancer tumors. VTX-2337 is a novel small m ...[more]