Induced pluripotent stem cell-derived cardiomyocytes: boutique science or valuable arrhythmia model?
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ABSTRACT:
SUBMITTER: Knollmann BC
PROVIDER: S-EPMC3667201 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Publications
Induced pluripotent stem cell-derived cardiomyocytes: boutique science or valuable arrhythmia model?
Circulation research 20130301 6
This article reviews the strengths and limitations of induced pluripotent stem cell-derived cardiomyocytes (iPSC-CM) as models of cardiac arrhythmias. Specifically, the article attempts to answer the following questions: Which clinical arrhythmias can be modeled by iPSC-CM? How well can iPSC-CM model adult ventricular myocytes? What are the strengths and limitations of published iPSC-CM arrhythmia models? What new mechanistic insight has been gained? What is the evidence that would support using ...[more]
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