Ontology highlight
ABSTRACT:
SUBMITTER: Kadoch C
PROVIDER: S-EPMC3667980 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Kadoch Cigall C Hargreaves Diana C DC Hodges Courtney C Elias Laura L Ho Lena L Ranish Jeff J Crabtree Gerald R GR
Nature genetics 20130505 6
Subunits of mammalian SWI/SNF (mSWI/SNF or BAF) complexes have recently been implicated as tumor suppressors in human malignancies. To understand the full extent of their involvement, we conducted a proteomic analysis of endogenous mSWI/SNF complexes, which identified several new dedicated, stable subunits not found in yeast SWI/SNF complexes, including BCL7A, BCL7B and BCL7C, BCL11A and BCL11B, BRD9 and SS18. Incorporating these new members, we determined mSWI/SNF subunit mutation frequency in ...[more]