Ontology highlight
ABSTRACT:
SUBMITTER: Haddad BR
PROVIDER: S-EPMC3668029 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Haddad Bassem R BR Gu Lei L Mirtti Tuomas T Dagvadorj Ayush A Vogiatzi Paraskevi P Hoang David T DT Bajaj Renu R Leiby Benjamin B Ellsworth Elyse E Blackmon Shauna S Ruiz Christian C Curtis Mark M Fortina Paolo P Ertel Adam A Liu Chengbao C Rui Hallgeir H Visakorpi Tapio T Bubendorf Lukas L Lallas Costas D CD Trabulsi Edouard J EJ McCue Peter P Gomella Leonard L Nevalainen Marja T MT
The American journal of pathology 20130507 6
The molecular mechanisms underlying progression of prostate cancer (PCa) to castrate-resistant (CR) and metastatic disease are poorly understood. Our previous mechanistic work shows that inhibition of transcription factor Stat5 by multiple alternative methods induces extensive rapid apoptotic death of Stat5-positive PCa cells in vitro and inhibits PCa xenograft tumor growth in nude mice. Furthermore, STAT5A/B induces invasive behavior of PCa cells in vitro and in vivo, suggesting involvement of ...[more]