Ontology highlight
ABSTRACT:
SUBMITTER: Leshner M
PROVIDER: S-EPMC4713128 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Leshner Marc M Devine Michelle M Roloff Gregory W GW True Lawrence D LD Misteli Tom T Meaburn Karen J KJ
Molecular biology of the cell 20151112 2
Genes occupy preferred spatial positions within interphase cell nuclei. However, positioning patterns are not an innate feature of a locus, and genes can alter their localization in response to physiological and pathological changes. Here we screen the radial positioning patterns of 40 genes in normal, hyperplasic, and malignant human prostate tissues. We find that the overall spatial organization of the genome in prostate tissue is largely conserved among individuals. We identify three genes wh ...[more]