Ontology highlight
ABSTRACT:
SUBMITTER: Michaud J
PROVIDER: S-EPMC3668359 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Genome research 20130328 6
In human transcriptional regulation, DNA-sequence-specific factors can associate with intermediaries that orchestrate interactions with a diverse set of chromatin-modifying enzymes. One such intermediary is HCFC1 (also known as HCF-1). HCFC1, first identified in herpes simplex virus transcription, has a poorly defined role in cellular transcriptional regulation. We show here that, in HeLa cells, HCFC1 is observed bound to 5400 generally active CpG-island promoters. Examination of the DNA sequenc ...[more]