Ontology highlight
ABSTRACT:
SUBMITTER: Deng T
PROVIDER: S-EPMC3753902 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Deng Tao T Zhu Z Iris ZI Zhang Shaofei S Leng Fenfei F Cherukuri Srujana S Hansen Loren L Mariño-Ramírez Leonardo L Meshorer Eran E Landsman David D Bustin Michael M
Molecular and cellular biology 20130617 16
Chromatin structure plays a key role in regulating gene expression and embryonic differentiation; however, the factors that determine the organization of chromatin around regulatory sites are not fully known. Here we show that HMGN1, a nucleosome-binding protein ubiquitously expressed in vertebrate cells, preferentially binds to CpG island-containing promoters and affects the organization of nucleosomes, DNase I hypersensitivity, and the transcriptional profile of mouse embryonic stem cells and ...[more]