Calretinin mediates apoptosis in small cell lung cancer cells expressing tetraspanin CD9.
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ABSTRACT:
SUBMITTER: He P
PROVIDER: S-EPMC3668526 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
Calretinin mediates apoptosis in small cell lung cancer cells expressing tetraspanin CD9.
He Ping P Kuhara Hanako H Tachibana Isao I Jin Yingji Y Takeda Yoshito Y Tetsumoto Satoshi S Minami Toshiyuki T Kohmo Satoshi S Hirata Haruhiko H Takahashi Ryo R Inoue Koji K Nagatomo Izumi I Kida Hiroshi H Kijima Takashi T Naka Tetsuji T Morii Eiichi E Kawase Ichiro I Kumanogoh Atsushi A
FEBS open bio 20130510
A majority of small cell lung cancer (SCLC) cells lack a metastasis suppressor, tetraspanin CD9, and CD9 expression promotes their apoptosis. By a proteomics-based approach, we compared an SCLC cell line with its CD9 transfectant and found that a calcium-binding neuronal protein, calretinin, is upregulated in CD9-positive SCLC cells. Ectopic or anticancer drug-induced CD9 expression upregulated calretinin, whereas CD9 knockdown down-regulated calretinin in SCLC cells. When calretinin was knocked ...[more]
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