AP-1/Fos-TGase2 axis mediates wounding-induced Plasmodium falciparum killing in Anopheles gambiae.
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ABSTRACT:
SUBMITTER: Nsango SE
PROVIDER: S-EPMC3668770 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Publications
AP-1/Fos-TGase2 axis mediates wounding-induced Plasmodium falciparum killing in Anopheles gambiae.
Nsango Sandrine E SE Pompon Julien J Xie Ting T Rademacher Annika A Fraiture Malou M Thoma Martine M Awono-Ambene Parfait H PH Moyou Roger S RS Morlais Isabelle I Levashina Elena A EA
The Journal of biological chemistry 20130416 22
Anopheline mosquitoes are the only vectors of human malaria worldwide. It is now widely accepted that mosquito immune responses play a crucial role in restricting Plasmodium development within the vector; therefore, further dissection of the molecular mechanisms underlying these processes should inform new vector control strategies urgently needed to roll back the disease. Here, using genome-wide transcriptional profiling, bioinformatics, and functional gene analysis, we identify a new axis of m ...[more]
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