Ontology highlight
ABSTRACT:
SUBMITTER: Michel K
PROVIDER: S-EPMC1636544 | biostudies-other | 2006 Nov
REPOSITORIES: biostudies-other
Michel Kristin K Suwanchaichinda Chansak C Morlais Isabelle I Lambrechts Louis L Cohuet Anna A Awono-Ambene Parfait H PH Simard Frederic F Fontenille Didier D Kanost Michael R MR Kafatos Fotis C FC
Proceedings of the National Academy of Sciences of the United States of America 20061025 45
Serpins are central to the modulation of various innate immune responses in insects and are suspected to influence the outcome of malaria parasite infection in mosquito vectors. Three Anopheles gambiae serpins (SRPN1, -2, and -3) were tested for their ability to inhibit the prophenoloxidase cascade, a key regulatory process in the melanization response. Recombinant SRPN1 and -2 can bind and inhibit a heterologous phenoloxidase-activating protease and inhibit phenoloxidase activation in vitro. Us ...[more]