Ontology highlight
ABSTRACT:
SUBMITTER: Oury F
PROVIDER: S-EPMC3668813 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Oury Franck F Ferron Mathieu M Huizhen Wang W Confavreux Cyrille C Xu Lin L Lacombe Julie J Srinivas Prashanth P Chamouni Alexandre A Lugani Francesca F Lejeune Herve H Kumar T Rajendra TR Plotton Ingrid I Karsenty Gerard G
The Journal of clinical investigation 20130601 6
The osteoblast-derived hormone osteocalcin promotes testosterone biosynthesis in the mouse testis by binding to GPRC6A in Leydig cells. Interestingly, Osteocalcin-deficient mice exhibit increased levels of luteinizing hormone (LH), a pituitary hormone that regulates sex steroid synthesis in the testes. These observations raise the question of whether LH regulates osteocalcin's reproductive effects. Additionally, there is growing evidence that osteocalcin levels are a reliable marker of insulin s ...[more]