Ontology highlight
ABSTRACT: Background
Although among women a decreasing prevalence of human papillomavirus (HPV) infection with increasing age has been consistently observed in high-resource countries, different age profiles have been reported elsewhere.Methods
We compared the age profile of high-risk (HR)-HPV prevalence in nine different areas of Northern and Central Italy by studying the women recruited in the intervention arm of the New Technologies in Cervical Cancer study and tested by Hybrid Capture 2. Differences in the age-distribution of HPV infection were investigated in each centre by the joinpoint approach in a logistic model. 46,900 women aged 25 to 60 years were included in the analysis.Results
The HR-HPV age-standardised (on Italian population) prevalence ranged from 5.7% (Trento) to 10.3% (Ravenna). HR-HPV prevalence decreased as a logistic function of increasing age in 6 of 9 centres (Trento, Verona, Florence, Bologna, Imola, and Viterbo). The effect of age on HR-HPV prevalence slopes did not differ significantly among these 6 centres, whereas significant heterogeneity in intercepts (p?ConclusionsOur results showed substantial differences in overall and age-specific HR-HPV prevalence across Italian areas. These findings may be related to different timing of changes in sexual behaviours across regions. Age-specific HR-HPV prevalence in Italy does not support an influence of age per se.
SUBMITTER: Baussano I
PROVIDER: S-EPMC3669053 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Baussano Iacopo I Franceschi Silvia S Gillio-Tos Anna A Carozzi Francesca F Carozzi Francesca F Confortini Massimo M Dalla Palma Paolo P De Lillo Margherita M Del Mistro Annarosa A De Marco Laura L Naldoni Carlo C Pierotti Paola P Schincaglia Patrizia P Segnan Nereo N Zorzi Manuel M Giorgi-Rossi Paolo P Ronco Guglielmo G
BMC infectious diseases 20130524
<h4>Background</h4>Although among women a decreasing prevalence of human papillomavirus (HPV) infection with increasing age has been consistently observed in high-resource countries, different age profiles have been reported elsewhere.<h4>Methods</h4>We compared the age profile of high-risk (HR)-HPV prevalence in nine different areas of Northern and Central Italy by studying the women recruited in the intervention arm of the New Technologies in Cervical Cancer study and tested by Hybrid Capture ...[more]