Ontology highlight
ABSTRACT:
SUBMITTER: Zhao J
PROVIDER: S-EPMC3669341 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Zhao Jin J Si Youhui Y Cheng Min M Yang Yang Y Niu Yuqiang Y Li Xiang X Liu Xiuying X Yang Wei W
PloS one 20130531 5
The cytokine interleukin-28B (IL-28B) has potential antiviral properties and regulatory roles in adaptive cellular immunity. A genome-wide association study identified a single nucleotide polymorphism near the IL-28B gene that strongly predicts response to hepatitis C treatment with interferon and ribavirin. In this study, we produced human serum albumin (HSA) fused to interleukin-28B (HSA-IL28B) in an attempt to determine the effects of albumin fusion on anti-Hepatitis C virus (HCV) activity an ...[more]