Ontology highlight
ABSTRACT:
SUBMITTER: Kulakova A
PROVIDER: S-EPMC7308280 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Kulakova Alina A Indrakumar Sowmya S Sønderby Tuelung Pernille P Mahapatra Sujata S Streicher Werner W WW Peters Günther H J GHJ Harris Pernille P
Scientific reports 20200622 1
Fusion technology is widely used in protein-drug development to increase activity, stability, and bioavailability of protein therapeutics. Fusion proteins, like any other type of biopharmaceuticals, need to remain stable during production and storage. Due to the high complexity and additional intramolecular interactions, it is not possible to predict the behavior of fusion proteins based on the behavior the individual proteins. Therefore, understanding the stability of fusion proteins on the mol ...[more]