Ontology highlight
ABSTRACT:
SUBMITTER: Golla U
PROVIDER: S-EPMC3669351 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Golla Upendarrao U Singh Vikash V Azad Gajendra Kumar GK Azad Gajendra Kumar GK Singh Prabhat P Verma Naveen N Mandal Papita P Chauhan Sakshi S Tomar Raghuvir S RS
PloS one 20130531 5
Gene expression is a multi-step process which requires recruitment of several factors to promoters. One of the factors, Sen1p is an RNA/DNA helicase implicated in transcriptional termination and RNA processing in yeast. In the present study, we have identified a novel function of Sen1p that regulates the expression of ribonucleotide reductase RNR1 gene, which is essential for maintaining genomic integrity. Cells with mutation in the helicase domain or lacking N-terminal domain of Sen1p displayed ...[more]