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Molecular signaling cascade of miRNAs in causing Diabetes Nephropathy.

ABSTRACT: Diabetic nephropathy (DN) is one of the major microvascular diseases and most common in diabetic patient, finally results in kidney failure. The main features of DN are basement membrane thickening, microalbuminuria, proteinuria, glomerular, mesangial hypertrophy and ECM protein accumulation. Recent discoveries have been shown that numerous pathways are activated during the development of DN in Diabetes mellitus. The small non-coding miRNA plays an important role in regulating the pathway which is involved in DN. In our study we consolidate different pathways which regulated by miRNAs in molecular signaling which results in causing DN. We embedded entire pathway in the form of regulatory network and we could able to understand that some of the miRNAs like miR-29 family, miR-377 and miR-25 would be able to control DN.

SUBMITTER: Padmashree DG

PROVIDER: S-EPMC3670122 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Molecular signaling cascade of miRNAs in causing Diabetes Nephropathy.

Padmashree Dyave Gowda DG Swamy Narayanaswamy Ramachandra NR

Bioinformation 20130430 8

Diabetic nephropathy (DN) is one of the major microvascular diseases and most common in diabetic patient, finally results in kidney failure. The main features of DN are basement membrane thickening, microalbuminuria, proteinuria, glomerular, mesangial hypertrophy and ECM protein accumulation. Recent discoveries have been shown that numerous pathways are activated during the development of DN in Diabetes mellitus. The small non-coding miRNA plays an important role in regulating the pathway which ...[more]

PMID: 23750089

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