Ontology highlight
ABSTRACT:
SUBMITTER: Deshpande S
PROVIDER: S-EPMC5934412 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Deshpande Supriya S Abdollahi Maryam M Wang Mei M Lanting Linda L Kato Mitsuo M Natarajan Rama R
Scientific reports 20180503 1
Autophagy plays a key role in the pathogenesis of kidney diseases, however its role in diabetic nephropathy (DN), and particularly in kidney glomerular mesangial cells (MCs) is not very clear. Transforming Growth Factor- β1 (TGF-β), a key player in the pathogenesis of DN, regulates expression of various microRNAs (miRNAs), some of which are known to regulate the expression of autophagy genes. Here we demonstrate that miR-192, induced by TGF-β signaling, plays an important role in regulating auto ...[more]