Ontology highlight
ABSTRACT:
SUBMITTER: Zhu YC
PROVIDER: S-EPMC3670390 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Proceedings of the National Academy of Sciences of the United States of America 20130513 22
The X-linked gene cyclin-dependent kinase-like 5 (CDKL5) is mutated in severe neurodevelopmental disorders, including some forms of atypical Rett syndrome, but the function and regulation of CDKL5 protein in neurons remain to be elucidated. Here, we show that CDKL5 binds to the scaffolding protein postsynaptic density (PSD)-95, and that this binding promotes the targeting of CDKL5 to excitatory synapses. Interestingly, this binding is not constitutive, but governed by palmitate cycling on PSD-95 ...[more]