Ontology highlight
ABSTRACT:
SUBMITTER: Stretch C
PROVIDER: S-EPMC3670871 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Stretch Cynthia C Khan Sheehan S Asgarian Nasimeh N Eisner Roman R Vaisipour Saman S Damaraju Sambasivarao S Graham Kathryn K Bathe Oliver F OF Steed Helen H Greiner Russell R Baracos Vickie E VE
PloS one 20130603 6
Top differentially expressed gene lists are often inconsistent between studies and it has been suggested that small sample sizes contribute to lack of reproducibility and poor prediction accuracy in discriminative models. We considered sex differences (69♂, 65 ♀) in 134 human skeletal muscle biopsies using DNA microarray. The full dataset and subsamples (n = 10 (5 ♂, 5 ♀) to n = 120 (60 ♂, 60 ♀)) thereof were used to assess the effect of sample size on the differential expression of single genes ...[more]