Protein corona significantly reduces active targeting yield.
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ABSTRACT:
SUBMITTER: Mirshafiee V
PROVIDER: S-EPMC3671387 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Publications
Protein corona significantly reduces active targeting yield.
Mirshafiee Vahid V Mahmoudi Morteza M Lou Kaiyan K Cheng Jianjun J Kraft Mary L ML
Chemical communications (Cambridge, England) 20130301 25
When nanoparticles (NPs) are exposed to the biological environment, their surfaces become covered with proteins and biomolecules (e.g. lipids). Here, we report that this protein coating, or corona, reduces the targeting capability of surface engineered NPs by screening the active sites of the targeting ligands. ...[more]
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