Ontology highlight
ABSTRACT:
SUBMITTER: Barbieri CE
PROVIDER: S-EPMC3673022 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Nature genetics 20120520 6
Prostate cancer is the second most common cancer in men worldwide and causes over 250,000 deaths each year. Overtreatment of indolent disease also results in significant morbidity. Common genetic alterations in prostate cancer include losses of NKX3.1 (8p21) and PTEN (10q23), gains of AR (the androgen receptor gene) and fusion of ETS family transcription factor genes with androgen-responsive promoters. Recurrent somatic base-pair substitutions are believed to be less contributory in prostate tum ...[more]