Ontology highlight
ABSTRACT:
SUBMITTER: Ying H
PROVIDER: S-EPMC3673586 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
International review of cell and molecular biology 20120101
Optineurin is a gene linked to glaucoma, amyotrophic lateral sclerosis, other neurodegenerative diseases, and Paget's disease of bone. This review describes the characteristics of optineurin and summarizes the cellular and molecular biology investigations conducted so far on optineurin. Data from a number of laboratories indicate that optineurin is a cytosolic protein containing 577 amino acid residues. Interacting with proteins such as myosin VI, Rab8, huntingtin, transferrin receptor, and TANK ...[more]