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Building bridges between cellular and molecular structural biology.

ABSTRACT: The integration of cellular and molecular structural data is key to understanding the function of macromolecular assemblies and complexes in their in vivo context. Here we report on the outcomes of a workshop that discussed how to integrate structural data from a range of public archives. The workshop identified two main priorities: the development of tools and file formats to support segmentation (that is, the decomposition of a three-dimensional volume into regions that can be associated with defined objects), and the development of tools to support the annotation of biological structures.

SUBMITTER: Patwardhan A

PROVIDER: S-EPMC5524535 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature

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Building bridges between cellular and molecular structural biology.

Patwardhan Ardan A Brandt Robert R Butcher Sarah J SJ Collinson Lucy L Gault David D Grünewald Kay K Hecksel Corey C Huiskonen Juha T JT Iudin Andrii A Jones Martin L ML Korir Paul K PK Koster Abraham J AJ Lagerstedt Ingvar I Lawson Catherine L CL Mastronarde David D McCormick Matthew M Parkinson Helen H Rosenthal Peter B PB Saalfeld Stephan S Saibil Helen R HR Sarntivijai Sirarat S Solanes Valero Irene I Subramaniam Sriram S Swedlow Jason R JR Tudose Ilinca I Winn Martyn M Kleywegt Gerard J GJ

eLife 20170706

The integration of cellular and molecular structural data is key to understanding the function of macromolecular assemblies and complexes in their in vivo context. Here we report on the outcomes of a workshop that discussed how to integrate structural data from a range of public archives. The workshop identified two main priorities: the development of tools and file formats to support segmentation (that is, the decomposition of a three-dimensional volume into regions that can be associated with ...[more]

PMID: 28682240

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