Ontology highlight
ABSTRACT:
SUBMITTER: Byeon IJ
PROVIDER: S-EPMC3674325 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Byeon In-Ja L IJ Ahn Jinwoo J Mitra Mithun M Byeon Chang-Hyeock CH Hercík Kamil K Hritz Jozef J Charlton Lisa M LM Levin Judith G JG Gronenborn Angela M AM
Nature communications 20130101
Human APOBEC3A is a single-stranded DNA cytidine deaminase that restricts viral pathogens and endogenous retrotransposons, and has a role in the innate immune response. Furthermore, its potential to act as a genomic DNA mutator has implications for a role in carcinogenesis. A deeper understanding of APOBEC3A's deaminase and nucleic acid-binding properties, which is central to its biological activities, has been limited by the lack of structural information. Here we report the nuclear magnetic re ...[more]