Ontology highlight
ABSTRACT:
SUBMITTER: Wang CI
PROVIDER: S-EPMC3674866 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Wang Charlotte I CI Alekseyenko Artyom A AA LeRoy Gary G Elia Andrew E H AE Gorchakov Andrey A AA Britton Laura-Mae P LM Elledge Stephen J SJ Kharchenko Peter V PV Garcia Benjamin A BA Kuroda Mitzi I MI
Nature structural & molecular biology 20130106 2
X-chromosome dosage compensation by the MSL (male-specific lethal) complex is required in Drosophila melanogaster to increase gene expression from the single male X to equal that of both female X chromosomes. Instead of focusing solely on protein complexes released from DNA, here we used chromatin-interacting protein MS (ChIP-MS) to identify MSL interactions on cross-linked chromatin. We identified MSL-enriched histone modifications, including histone H4 Lys16 acetylation and histone H3 Lys36 me ...[more]