Ontology highlight
ABSTRACT:
SUBMITTER: Azad N
PROVIDER: S-EPMC3674958 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Azad Nilofer N Dasari Arvind A Arcaroli John J Taylor Gretchen E GE Laheru Daniel A DA Carducci Michael A MA McManus Martine M Quackenbush Kevin K Wright John J JJ Hidalgo Manuel M Diaz Luis A LA Donehower Ross C RC Zhao Ming M Rudek Michelle A MA Messersmith Wells A WA
Investigational new drugs 20120522 2
Background This phase Ib study was designed to determine the maximum tolerated doses (MTD) and dose limiting toxicities (DLTs) of irinotecan and cetuximab with sorafenib. Secondary objectives included characterizing the pharmacokinetics and pharmacodynamics and evaluating preliminary antitumor activity in patients with advanced colorectal cancer (CRC). Methods Patients with metastatic, pretreated CRC were treated at five dose levels. Results Eighteen patients were recruited with median age 56.5 ...[more]