Ontology highlight
ABSTRACT:
SUBMITTER: Hong DS
PROVIDER: S-EPMC5562357 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Hong David S DS Morris Van K VK El Osta Badi B Sorokin Alexey V AV Janku Filip F Fu Siqing S Overman Michael J MJ Piha-Paul Sarina S Subbiah Vivek V Kee Bryan B Tsimberidou Apostolia M AM Fogelman David D Bellido Jorge J Shureiqi Imad I Huang Helen H Atkins Johnique J Tarcic Gabi G Sommer Nicolas N Lanman Richard R Meric-Bernstam Funda F Kopetz Scott S
Cancer discovery 20161011 12
In vitro, EGFR inhibition, combined with the BRAF inhibitor vemurafenib, causes synergistic cytotoxicity for BRAF<sup>V600E</sup> metastatic colorectal cancer, further augmented by irinotecan. The safety and efficacy of vemurafenib, irinotecan, and cetuximab in BRAF-mutated malignancies are not defined. In this 3+3 phase I study, patients with BRAF<sup>V600E</sup>-advanced solid cancers received cetuximab and irinotecan with escalating doses of vemurafenib. Nineteen patients (18 with metastatic ...[more]