Ontology highlight
ABSTRACT:
SUBMITTER: Long N
PROVIDER: S-EPMC3675126 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Long Nanye N Dickson Samuel P SP Maia Jessica M JM Kim Hee Shin HS Zhu Qianqian Q Allen Andrew S AS
PLoS computational biology 20130606 6
Although many methods are available to test sequence variants for association with complex diseases and traits, methods that specifically seek to identify causal variants are less developed. Here we develop and evaluate a Bayesian hierarchical regression method that incorporates prior information on the likelihood of variant causality through weighting of variant effects. By simulation studies using both simulated and real sequence variants, we compared a standard single variant test for analyzi ...[more]