Incorporating prior biologic information for high-dimensional rare variant association studies.
Ontology highlight
ABSTRACT:
SUBMITTER: Quintana MA
PROVIDER: S-EPMC4058572 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Publications
Incorporating prior biologic information for high-dimensional rare variant association studies.
Quintana Melanie A MA Schumacher Fredrick R FR Casey Graham G Bernstein Jonine L JL Li Li L Conti David V DV
Human heredity 20120101 3-4
<h4>Background</h4>Given the increasing scale of rare variant association studies, we introduce a method for high-dimensional studies that integrates multiple sources of data as well as allows for multiple region-specific risk indices.<h4>Methods</h4>Our method builds upon the previous Bayesian risk index by integrating external biological variant-specific covariates to help guide the selection of associated variants and regions. Our extension also incorporates a second level of uncertainty as t ...[more]
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