Canine distemper virus associated with a lethal outbreak in monkeys can readily adapt to use human receptors.

ABSTRACT: A canine distemper virus (CDV) strain, CYN07-dV, associated with a lethal outbreak in monkeys, used human signaling lymphocyte activation molecule as a receptor only poorly but readily adapted to use it following a P541S substitution in the hemagglutinin protein. Since CYN07-dV had an intrinsic ability to use human nectin-4, the adapted virus became able to use both human immune and epithelial cell receptors, as well as monkey and canine ones, suggesting that CDV can potentially infect humans.

SUBMITTER: Sakai K 

PROVIDER: S-EPMC3676118 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature