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ABSTRACT:
SUBMITTER: Cifuente JO
PROVIDER: S-EPMC3677187 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Cifuente Javier O JO Ferrer María F MF Jaquenod de Giusti Carolina C Song Wen-Chao WC Romanowski Víctor V Hafenstein Susan L SL Gómez Ricardo M RM
Journal of medical virology 20110901 9
To understand better how different genomic regions may confer pathogenicity for the coxsackievirus B (CVB), two intratypic CVB1 variants, and a number of recombinant viruses were studied. Sequencing analysis showed 23 nucleotide changes between the parental non-pathogenic CVB1N and the pathogenic CVB1Nm. Mutations present in CVB1Nm were more conserved than those in CVB1N when compared to other CVB sequences. Inoculation in C3H/HeJ mice showed that the P1 region is critical for pathogenicity in m ...[more]