Ontology highlight
ABSTRACT:
SUBMITTER: Langlois AC
PROVIDER: S-EPMC7419504 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Langlois Anne-Claire AC Manzoni Giulia G Vincensini Laetitia L Coppée Romain R Marinach Carine C Guérin Maryse M Huby Thierry T Carrière Véronique V Cosset François-Loïc FL Dreux Marlène M Rubinstein Eric E Silvie Olivier O
Scientific reports 20200811 1
Sporozoite forms of the Plasmodium parasite, the causative agent of malaria, are transmitted by mosquitoes and first infect the liver for an initial round of replication before parasite proliferation in the blood. The molecular mechanisms involved during sporozoite invasion of hepatocytes remain poorly understood. Two receptors of the Hepatitis C virus (HCV), the tetraspanin CD81 and the scavenger receptor class B type 1 (SR-B1), play an important role during the entry of Plasmodium sporozoites ...[more]