Vitronectin improves cell survival after radiation injury in human umbilical vein endothelial cells.
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ABSTRACT:
SUBMITTER: Hazawa M
PROVIDER: S-EPMC3678119 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
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Vitronectin improves cell survival after radiation injury in human umbilical vein endothelial cells.
Hazawa Masaharu M Yasuda Takeshi T Noshiro Katsuko K Saotome-Nakamura Ai A Fukuzaki Tomoko T Michikawa Yuichi Y Gotoh Takaya T Tajima Katsushi K
FEBS open bio 20121017
Vitronectin (VN) is a multi-functional protein involved in extracellular matrix (ECM)-cell binding through integrin receptors on the cell surface, which is an important environmental process for maintaining biological homeostasis. We investigated how VN affects the survival of endothelial cells after radiation damage. VN attenuated radiation-induced expression of p21, an inhibitor of cell cycle progression, and selectively inhibited Erk- and p38 MAPK-dependent p21 induction after radiation expos ...[more]
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