Resolvin E1 maintains macrophage function under cigarette smoke-induced oxidative stress.
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ABSTRACT:
SUBMITTER: Takamiya R
PROVIDER: S-EPMC3678121 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Publications
Resolvin E1 maintains macrophage function under cigarette smoke-induced oxidative stress.
Takamiya Rina R Fukunaga Koichi K Arita Makoto M Miyata Jun J Seki Hiroyuki H Minematsu Naoto N Suematsu Makoto M Asano Koichiro K
FEBS open bio 20121017
Cigarette smoke (CS) induces oxidative stress, which disables macrophage function. In this study, we examined whether Resolvin E1 (RvE1), a pro-resolving mediator known to enhance macrophage functions, attenuates the damage of macrophages by CS extract (CSE) induced oxidative stress. RvE1 blocked p47phox translocation to plasma membrane induced by CSE in a macrophage cell line, RAW264.7 cells, resulting in suppression of superoxide production. Furthermore, pretreatment of RAW264.7 cells with RvE ...[more]
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