Ontology highlight
ABSTRACT:
SUBMITTER: Sanders KA
PROVIDER: S-EPMC6338799 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Sanders Karl A KA Delker Don A DA Huecksteadt Tom T Beck Emily E Wuren Tanna T Chen Yuntian Y Zhang Yuxia Y Hazel Mark W MW Hoidal John R JR
Scientific reports 20190118 1
The receptor for advanced glycation end products (RAGE), a cell membrane receptor, recognizes ligands produced by cigarette smoke (CS) and has been implicated in the pathogenesis of COPD. We demonstrate that deletion or pharmacologic inhibition of RAGE prevents development of CS-induced emphysema. To identify molecular pathways by which RAGE mediates smoking related lung injury we performed unbiased gene expression profiling of alveolar macrophages (AM) obtained from RAGE null and C57BL/6 WT mic ...[more]