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Synthesis of kojic acid derivatives as secondary binding site probes of D-amino acid oxidase.

ABSTRACT: A series of kojic acid (5-hydroxy-2-hydroxymethyl-4H-pyran-4-one) derivatives were synthesized and tested for their ability to inhibit D-amino acid oxidase (DAAO). Various substituents were incorporated into kojic acid at its 2-hydroxymethyl group. These analogs serve as useful molecular probes to explore the secondary binding site, which can be exploited in designing more potent DAAO inhibitors.

SUBMITTER: Raje M

PROVIDER: S-EPMC3678123 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature

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Synthesis of kojic acid derivatives as secondary binding site probes of D-amino acid oxidase.

Raje Mithun M Hin Niyada N Duvall Bridget B Ferraris Dana V DV Berry James F JF Thomas Ajit G AG Alt Jesse J Rojas Camilo C Slusher Barbara S BS Tsukamoto Takashi T

Bioorganic & medicinal chemistry letters 20130501 13

A series of kojic acid (5-hydroxy-2-hydroxymethyl-4H-pyran-4-one) derivatives were synthesized and tested for their ability to inhibit D-amino acid oxidase (DAAO). Various substituents were incorporated into kojic acid at its 2-hydroxymethyl group. These analogs serve as useful molecular probes to explore the secondary binding site, which can be exploited in designing more potent DAAO inhibitors. ...[more]

PMID: 23683589

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