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Synthesis of kojic acid derivatives as secondary binding site probes of D-amino acid oxidase.


ABSTRACT: A series of kojic acid (5-hydroxy-2-hydroxymethyl-4H-pyran-4-one) derivatives were synthesized and tested for their ability to inhibit D-amino acid oxidase (DAAO). Various substituents were incorporated into kojic acid at its 2-hydroxymethyl group. These analogs serve as useful molecular probes to explore the secondary binding site, which can be exploited in designing more potent DAAO inhibitors.

SUBMITTER: Raje M 

PROVIDER: S-EPMC3678123 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature

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Synthesis of kojic acid derivatives as secondary binding site probes of D-amino acid oxidase.

Raje Mithun M   Hin Niyada N   Duvall Bridget B   Ferraris Dana V DV   Berry James F JF   Thomas Ajit G AG   Alt Jesse J   Rojas Camilo C   Slusher Barbara S BS   Tsukamoto Takashi T  

Bioorganic & medicinal chemistry letters 20130501 13


A series of kojic acid (5-hydroxy-2-hydroxymethyl-4H-pyran-4-one) derivatives were synthesized and tested for their ability to inhibit D-amino acid oxidase (DAAO). Various substituents were incorporated into kojic acid at its 2-hydroxymethyl group. These analogs serve as useful molecular probes to explore the secondary binding site, which can be exploited in designing more potent DAAO inhibitors. ...[more]

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