Ontology highlight
ABSTRACT:
SUBMITTER: Siebert A
PROVIDER: S-EPMC7173178 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Siebert Agnieszka A Wysocka Magdalena M Krawczyk Beata B Cholewiński Grzegorz G Rachoń Janusz J
European journal of medicinal chemistry 20171201
The series of 16 novel amino acid and peptide mycophenolic acid (MPA) derivatives was obtained as potential antibacterial agents. Coupling of MPA with respective amines was optimized with condensing reagents such as EDCI/DMAP and T3P/TEA. Amino acid analogs were received both as methyl esters and also with the free carboxylic group. The biological activity of the products was tested on five references bacterial strains: Klebsiella pneumoniae ATCC 700603 (ESBL), Escherichia coli ATCC 8739, Pseudo ...[more]