Ontology highlight
ABSTRACT:
SUBMITTER: Jing J
PROVIDER: S-EPMC3679202 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Jing Jian J Yang Ivana V IV Hui Lucy L Patel Jay A JA Evans Christopher M CM Prikeris Rytis R Kobzik Lester L O'Connor Brian P BP Schwartz David A DA
Journal of immunology (Baltimore, Md. : 1950) 20130510 12
Macrophages play a key role in host defense against microbes, in part, through phagocytosis. Macrophage receptor with collagenous structure (MARCO) is a scavenger receptor on the cell surface of macrophages that mediates opsonin-independent phagocytosis. The goal of our study is to investigate the role of MARCO in LPS or lipotechoic acid-induced macrophage tolerance. Although it has been established that expression of MARCO and phagocytosis is increased in tolerant macrophages, the transcription ...[more]